Response of human skeletal muscle to the anabolic steroid stanozolol.
نویسندگان
چکیده
The prevalence of polycystic ovaries in the women who had had recurrent miscarriages was high (82%). Although the number of parous control women was small, their prevalence of polycystic ovaries (18%) was similar to that observed in a much larger population of normal women (22%).3 The normal serum luteinising hormone and urine pregnanediol-3a-glucuronide concentrations suggest that the endocrine abnormalities typical of women with polycystic ovaries who do not ovulate did not occur in the women we studied who ovulated spontaneously. This, however, is consistent with our previous findings that luteinising hormone concentrations are usually normal in women with polycystic ovaries who ovulate but are hirsute, and that three quarters of the women in the normal population who are diagnosed as having polycystic ovaries have normal serum luteinising hormone concentrations.23 A raised serum luteinising hormone concentration may be a risk factor for early miscarriage.4 Women with polycystic ovaries who conceive after induction of ovulation with pulsatile luteinising hormone releasing hormone have an increased rate of early loss of pregnancy compared with hypogonadotrophic patients. Serum luteinising hormone concentrations were higher, particularly during the follicular phase, in women with polycystic ovaries who had an early pregnancy loss compared with those whose pregnancies progressed to term.4 Serial blood sampling and ultrasonography are required to establish whether patients who have recurrent miscarriages have inappropriately high luteinising hormone concentrations at some particular point in their menstrual cycle. Another possibility is that the increased risk of early miscarriage in women with polycystic ovaries results from an abnormal endometrial environment in early pregnancy.5 Endometrial changes may in turn be linked to the abnormal production of immunoglobulins by decidual cells thought to occur in women who have recurrent miscarriages.
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ورودعنوان ژورنال:
- BMJ
دوره 297 6655 شماره
صفحات -
تاریخ انتشار 1988